Interaction Between Hb Hasharon and a - Thalassemia : An Approach to the Problem of the Number ofHuman a Loci
نویسندگان
چکیده
We report the case of an Italian infant girl hand, in the Askenazy carriers of Hb Hafrom Polesine (Po delta region in northern sharon, Hb Hasharon is probably linked to Italy) who was heterozygous for Hb Haa normal a gene. In comparing Hb Hasharon and a-thalassemia, did not synthesharon’s behavior with that of other a size any normal HbA, and had 3% HbH on variants, particularly HbG Philadelphia, electrophoresis. Hematologic and biosynfrequent recombinations between a structhetic studies on Hb Hasharon carriers of tural genes were suggested. The possible the propositus’ family suggest the possibilidentity between the single a locus and ity that the Hb Hasharon gene is linked to the a2-thalassemia genotype is disan a-thalassemia gene. On the other cussed.
منابع مشابه
A New Approach Based on Erythrocyte Indices to Exclude Normal Populations from Chromatography Based Thalassemia Screening Programs with Very High Fidelity
Background: Screening and counselling is the most effective way to prevent the birth of children with thalassemia major. An accurate and relatively less time-consuming protocol is necessary to screen large populations. Separating iron deficiency anaemia from thalassemia trait based on blood cell parameters has been used by hematologists for many years. We aimed to design a new approach to scree...
متن کاملIdentification of a Neonate with Thalassemia Intermedia Despite Premarital Screening Program in Mazandaran Province (Co-inheritance of Hb Knossos and IVS II-1 G> A Mutations)
Background: Beta thalassemia is a common health problem in Iran especially in Northern provinces. Premarital screening for thalassemia is compulsory in Iran and identification of the carriers is based on primary CBC (Cell Blood Count) and hemoglobin electrophoresis. Silent mutations on β-globin gene have borderline or normal hematological indices that cannot be detected in premarital scree...
متن کاملHemoglobin E/β⁰ Thalassemia in south west Iran - A case series
Background: Beta thalassemia gene mutations are among common mutations in southwest Iran. However, Hemoglobin E (Hb E) and Hb E/β⁰ thalassemia account for a small number of hemoglobinopathies in Iran. This is the first study to directly address the existence of Hb E and consequently Hb E/β⁰ thalassemia in southwest Iran. Methods: This retrospective study discovered seven cases of Hb E/β⁰ thal...
متن کاملKinematic and Dynamic Analysis of Tripteron, an Over-constrained 3-DOF Translational Parallel Manipulator, Through Newton-Euler Approach
In this research, as the main contribution, a comprehensive study is carried out on the mathematical modeling and analysis of the inverse kinematics and dynamics of an over-constraint three translational degree-of-freedom parallel manipulator. Due to the inconsistency between the number of equations and unknowns, the problem of obtaining the constraint forces and torques of an over-constraint m...
متن کاملPrevalence of Hemoglobin Mutations and Hemoglobinopathies in Masjed Soleiman County, Southeastern Iran
ABSTRACT Background and Objectives: Hemoglobinopathies are characterized by defects in the synthesis of globin chains of hemoglobin (Hb). The purpose of the present study was to evaluate mutations associated with thalassemia and other hemoglobinopathies in Masjed Soleiman County, Iran. Methods: This descriptive study was carried out on 456 individuals suspected of ha...
متن کامل